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Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives

[Image: see text] An in silico study, using the GALAS algorithm available in ACD/PhysChem Suite, was performed to calculate the pK(a)(s) of various oximes with potential application as peptide coupling additives. Among the known oximes and predicted structures, OxymaPure is superior based on the pK(...

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Detalles Bibliográficos
Autores principales: Manne, Srinivasa Rao, Sharma, Anamika, Sazonovas, Andrius, El-Faham, Ayman, de la Torre, Beatriz G., Albericio, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8867806/
https://www.ncbi.nlm.nih.gov/pubmed/35224362
http://dx.doi.org/10.1021/acsomega.1c06342