LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain

Age-related decline in mitochondrial function and oxidative stress plays a critical role in neurodegeneration. Lactate dehydrogenase-B (LDHB) is a glycolytic enzyme that catalyzes the conversion of lactate, an important brain energy substrate, into pyruvate. It has been reported that the LDHB patter...

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Detalles Bibliográficos
Autores principales: Park, Jun Sung, Saeed, Kamran, Jo, Myeung Hoon, Kim, Min Woo, Lee, Hyeon Jin, Park, Chan-Bae, Lee, Gwang, Kim, Myeong Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868245/
https://www.ncbi.nlm.nih.gov/pubmed/35204143
http://dx.doi.org/10.3390/antiox11020261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868245/
https://www.ncbi.nlm.nih.gov/pubmed/35204143
http://dx.doi.org/10.3390/antiox11020261

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