Structure–Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors

To evaluate the differences in action of commercially available 2-oxoglutarate mimetics and “branched-tail” oxyquinoline inhibitors of hypoxia-inducible factor prolyl hydroxylase (HIF PHD), the inhibitors’ IC(50) values in the activation of HIF1 ODD-luciferase reporter were selected for comparative...

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Detalles Bibliográficos
Autores principales: Poloznikov, Andrey A., Nikulin, Sergey V., Hushpulian, Dmitry M., Khristichenko, Anna Yu., Osipyants, Andrey I., Asachenko, Andrey F., Shurupova, Olga V., Savin, Svyatoslav S., Lee, Sue H., Gaisina, Irina N., Thatcher, Gregory R. J., Narciso, Anthony, Chang, Eric P., Kazakov, Sergey V., Krucher, Nancy, Tishkov, Vladimir I., Thomas, Bobby, Gazaryan, Irina G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868400/
https://www.ncbi.nlm.nih.gov/pubmed/35204103
http://dx.doi.org/10.3390/antiox11020220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868400/
https://www.ncbi.nlm.nih.gov/pubmed/35204103
http://dx.doi.org/10.3390/antiox11020220

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