NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR

NF-E2-related factor 2 (NRF2), an antioxidant transcription factor, is activated in autophagy-deficient mice due to the accumulations of p62/SQSTM1 and its subsequent interaction with Kelch-like-ECH-associated protein 1 (KEAP1), an adaptor component for Cullin3-based E3 ubiquitin ligase complex. Far...

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Detalles Bibliográficos
Autores principales: Kim, Eun Young, Lee, Jae Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868494/
https://www.ncbi.nlm.nih.gov/pubmed/35204252
http://dx.doi.org/10.3390/antiox11020370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868494/
https://www.ncbi.nlm.nih.gov/pubmed/35204252
http://dx.doi.org/10.3390/antiox11020370

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