LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria

The accumulation of deleterious mitochondrial DNA (ΔmtDNA) causes inherited mitochondrial diseases and aging-associated decline in mitochondrial functions such as oxidative phosphorylation (OXPHOS) function. Upon mitochondrial perturbations, the bZIP protein ATFS-1 induces a transcription program to...

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Detalles Bibliográficos
Autores principales: Yang, Qiyuan, Liu, Pengpeng, Anderson, Nadine S., Shpilka, Tomer, Du, YunGuang, Naresh, Nandhitha Uma, Li, Rui, Zhu, Lihua Julie, Luk, Kevin, Lavelle, Josh, Zeinert, Rilee D., Chien, Peter, Wolfe, Scot A., Haynes, Cole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868506/
https://www.ncbi.nlm.nih.gov/pubmed/35165413
http://dx.doi.org/10.1038/s41556-021-00840-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868506/
https://www.ncbi.nlm.nih.gov/pubmed/35165413
http://dx.doi.org/10.1038/s41556-021-00840-5

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