Expression Profiling in Ovarian Cancer Reveals Coordinated Regulation of BRCA1/2 and Homologous Recombination Genes

Predictive biomarkers are crucial in clarifying the best strategy to use poly(ADP-ribose) polymerase inhibitors (PARPi) for the greatest benefit to ovarian cancer patients. PARPi are specifically lethal to cancer cells that cannot repair DNA damage by homologous recombination (HR), and HR deficiency...

Descripción completa

Detalles Bibliográficos
Autores principales: Custódio, Noélia, Savisaar, Rosina, Carvalho, Célia, Bak-Gordon, Pedro, Ribeiro, Maria I., Tavares, Joana, Nunes, Paula B., Peixoto, Ana, Pinto, Carla, Escudeiro, Carla, Teixeira, Manuel R., Carmo-Fonseca, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868827/
https://www.ncbi.nlm.nih.gov/pubmed/35203410
http://dx.doi.org/10.3390/biomedicines10020199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868827/
https://www.ncbi.nlm.nih.gov/pubmed/35203410
http://dx.doi.org/10.3390/biomedicines10020199

Ejemplares similares