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Expression Profiling in Ovarian Cancer Reveals Coordinated Regulation of BRCA1/2 and Homologous Recombination Genes

Predictive biomarkers are crucial in clarifying the best strategy to use poly(ADP-ribose) polymerase inhibitors (PARPi) for the greatest benefit to ovarian cancer patients. PARPi are specifically lethal to cancer cells that cannot repair DNA damage by homologous recombination (HR), and HR deficiency...

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Detalles Bibliográficos
Autores principales:	Custódio, Noélia, Savisaar, Rosina, Carvalho, Célia, Bak-Gordon, Pedro, Ribeiro, Maria I., Tavares, Joana, Nunes, Paula B., Peixoto, Ana, Pinto, Carla, Escudeiro, Carla, Teixeira, Manuel R., Carmo-Fonseca, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8868827/ https://www.ncbi.nlm.nih.gov/pubmed/35203410 http://dx.doi.org/10.3390/biomedicines10020199

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