High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition

SIMPLE SUMMARY: Cardiovascular disease is the leading cause of death for people of most ethnicities in the United States. The human ether-a-go-go-related gene (hERG) potassium channel plays a pivotal role in cardiac rhythm regulation, and cardiotoxicity associated with hERG inhibition by drug molecu...

Descripción completa

Detalles Bibliográficos
Autores principales: Krishna, Shagun, Borrel, Alexandre, Huang, Ruili, Zhao, Jinghua, Xia, Menghang, Kleinstreuer, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869358/
https://www.ncbi.nlm.nih.gov/pubmed/35205076
http://dx.doi.org/10.3390/biology11020209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869358/
https://www.ncbi.nlm.nih.gov/pubmed/35205076
http://dx.doi.org/10.3390/biology11020209

Ejemplares similares