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High-Throughput Chemical Screening and Structure-Based Models to Predict hERG Inhibition

SIMPLE SUMMARY: Cardiovascular disease is the leading cause of death for people of most ethnicities in the United States. The human ether-a-go-go-related gene (hERG) potassium channel plays a pivotal role in cardiac rhythm regulation, and cardiotoxicity associated with hERG inhibition by drug molecu...

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Detalles Bibliográficos
Autores principales:	Krishna, Shagun, Borrel, Alexandre, Huang, Ruili, Zhao, Jinghua, Xia, Menghang, Kleinstreuer, Nicole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869358/ https://www.ncbi.nlm.nih.gov/pubmed/35205076 http://dx.doi.org/10.3390/biology11020209

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