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Lung Fibroblasts from Idiopathic Pulmonary Fibrosis Patients Harbor Short and Unstable Telomeres Leading to Chromosomal Instability
Idiopathic pulmonary fibrosis (IPF) is associated with several hallmarks of aging including telomere shortening, which can result from germline mutations in telomere related genes (TRGs). Here, we assessed the length and stability of telomeres as well as the integrity of chromosomes in primary lung...
Autores principales: | M’Kacher, Radhia, Jaillet, Madeleine, Colicchio, Bruno, Vasarmidi, Eirini, Mailleux, Arnaud, Dieterlen, Alain, Kannengiesser, Caroline, Borie, Claire, Oudrhiri, Noufissa, Junker, Steffen, Voisin, Philippe, Jeandidier, Eric, Carde, Patrice, Fenech, Michael, Bennaceur-Griscelli, Annelise, Crestani, Bruno, Borie, Raphael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869717/ https://www.ncbi.nlm.nih.gov/pubmed/35203522 http://dx.doi.org/10.3390/biomedicines10020310 |
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