KasQ an Epimerase Primes the Biosynthesis of Aminoglycoside Antibiotic Kasugamycin and KasF/H Acetyltransferases Inactivate Its Activity

Kasugamycin (KSM), an aminoglycoside antibiotic, is composed of three chemical moieties: D-chiro-inositol, kasugamine and glycine imine. Despite being discovered more than 50 years ago, the biosynthetic pathway of KSM remains an unresolved puzzle. Here we report a structural and functional analysis...

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Detalles Bibliográficos
Autores principales: Rattinam, Rajesh, Basha, R. Sidick, Wang, Yung-Lin, Wang, Zhe-Chong, Hsu, Ning-Shian, Lin, Kuan-Hung, Zadeh, Saeid Malek, Adhikari, Kamal, Lin, Jin-Ping, Li, Tsung-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869731/
https://www.ncbi.nlm.nih.gov/pubmed/35203422
http://dx.doi.org/10.3390/biomedicines10020212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869731/
https://www.ncbi.nlm.nih.gov/pubmed/35203422
http://dx.doi.org/10.3390/biomedicines10020212

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