Cargando…
Early Cellular, Molecular, Morphological and Behavioral Changes in the Humanized Amyloid-Beta-Knock-In Mouse Model of Late-Onset Alzheimer’s Disease
The purpose of our study is to investigate early cellular, molecular, morphological and behavioral changes in humanized amyloid-beta-knock-in (hAbKI) mice. Using seven-month-old homozygous hAbKI mice, we studied behavioral phenotype parameters, including spatial learning and memory (Morris Water Maz...
Autores principales: | Kshirsagar, Sudhir, Alvir, Rainier Vladlen, Hindle, Ashly, Kumar, Subodh, Vijayan, Murali, Pradeepkiran, Jangampalli Adi, Reddy, Arubala P., Ramasubramanian, Bhagavathi, Reddy, P. Hemachandra |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8869866/ https://www.ncbi.nlm.nih.gov/pubmed/35203382 http://dx.doi.org/10.3390/cells11040733 |
Ejemplares similares
-
A Combination Therapy of Urolithin A+EGCG Has Stronger Protective Effects than Single Drug Urolithin A in a Humanized Amyloid Beta Knockin Mice for Late-Onset Alzheimer’s Disease
por: Kshirsagar, Sudhir, et al.
Publicado: (2022) -
Are mitophagy enhancers therapeutic targets for Alzheimer’s disease?
por: Pradeepkiran, Jangampalli Adi, et al.
Publicado: (2022) -
A partial reduction of VDAC1 enhances mitophagy, autophagy, synaptic activities in a transgenic Tau mouse model
por: Vijayan, Murali, et al.
Publicado: (2022) -
Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights
por: Reddy, P. Hemachandra, et al.
Publicado: (2023) -
Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease?
por: Hindle, Ashly, et al.
Publicado: (2022)