Impaired Function of PLEKHG2, a Rho-Guanine Nucleotide-Exchange Factor, Disrupts Corticogenesis in Neurodevelopmental Phenotypes

Homozygosity of the p.Arg204Trp variation in the Pleckstrin homology and RhoGEF domain containing G2 (PLEKHG2) gene, which encodes a Rho family-specific guanine nucleotide-exchange factor, is responsible for microcephaly with intellectual disability. However, the role of PLEKHG2 during neurodevelopm...

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Detalles Bibliográficos
Autores principales: Nishikawa, Masashi, Ito, Hidenori, Tabata, Hidenori, Ueda, Hiroshi, Nagata, Koh-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870177/
https://www.ncbi.nlm.nih.gov/pubmed/35203342
http://dx.doi.org/10.3390/cells11040696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870177/
https://www.ncbi.nlm.nih.gov/pubmed/35203342
http://dx.doi.org/10.3390/cells11040696

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