Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of GATA1 and STAG2 Mutations in Induced Pluripotent Stem Cells with Trisomy 21

Children with Down syndrome (DS) have a high risk for acute myeloid leukemia (DS-ML). Genomic characterization of DS-ML blasts showed the presence of unique mutations in GATA1, an essential hematopoietic transcription factor, leading to the production of a truncated from of GATA1 (GATA1s). GATA1s, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Barwe, Sonali P., Sebastian, Aimy, Sidhu, Ishnoor, Kolb, Edward Anders, Gopalakrishnapillai, Anilkumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870267/
https://www.ncbi.nlm.nih.gov/pubmed/35203280
http://dx.doi.org/10.3390/cells11040628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870267/
https://www.ncbi.nlm.nih.gov/pubmed/35203280
http://dx.doi.org/10.3390/cells11040628

Ejemplares similares