Everything Comes with a Price: The Toxicity Profile of DNA-Damage Response Targeting Agents

SIMPLE SUMMARY: DNA damage induces genome instability, which may elicit cancer development. Defects in the DNA repair machinery further enhance cancer predisposition, but can also be exploited as a therapeutic target. Indeed, targeted agents against specific components of DNA repair, such as PARP in...

Descripción completa

Detalles Bibliográficos
Autores principales: Martorana, Federica, Da Silva, Leandro Apolinario, Sessa, Cristiana, Colombo, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870347/
https://www.ncbi.nlm.nih.gov/pubmed/35205700
http://dx.doi.org/10.3390/cancers14040953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870347/
https://www.ncbi.nlm.nih.gov/pubmed/35205700
http://dx.doi.org/10.3390/cancers14040953

Ejemplares similares