MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients’ Cells

Progeroid syndromes (PS), including Hutchinson-Gilford Progeria Syndrome (HGPS), are premature and accelerated aging diseases, characterized by clinical features mimicking physiological aging. Most classical HGPS patients carry a de novo point mutation within exon 11 of the LMNA gene encoding A-type...

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Detalles Bibliográficos
Autores principales: Harhouri, Karim, Cau, Pierre, Casey, Frank, Guedenon, Koffi Mawuse, Doubaj, Yassamine, Van Maldergem, Lionel, Mejia-Baltodano, Gerardo, Bartoli, Catherine, De Sandre-Giovannoli, Annachiara, Lévy, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870437/
https://www.ncbi.nlm.nih.gov/pubmed/35203262
http://dx.doi.org/10.3390/cells11040610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870437/
https://www.ncbi.nlm.nih.gov/pubmed/35203262
http://dx.doi.org/10.3390/cells11040610

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