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PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage

PINK1 is a causative gene for Parkinson’s disease and the corresponding protein has been identified as a master regulator of mitophagy—the autophagic degradation of damaged mitochondria. It interacts with Beclin1 to regulate autophagy and initiate autophagosome formation, even outside the context of...

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Detalles Bibliográficos
Autores principales: Brunelli, Francesco, Torosantucci, Liliana, Gelmetti, Vania, Franzone, Davide, Grünewald, Anne, Krüger, Rejko, Arena, Giuseppe, Valente, Enza Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870463/
https://www.ncbi.nlm.nih.gov/pubmed/35203326
http://dx.doi.org/10.3390/cells11040678