PU.1 Expression Defines Distinct Functional Activities in the Phenotypic HSC Compartment of a Murine Inflammatory Stress Model

The transcription factor PU.1 is a critical regulator of lineage fate in blood-forming hematopoietic stem cells (HSC). In response to pro-inflammatory signals, such as the cytokine IL-1β, PU.1 expression is increased in HSC and is associated with myeloid lineage expansion. To address potential funct...

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Detalles Bibliográficos
Autores principales: Chavez, James S., Rabe, Jennifer L., Hernandez, Giovanny, Mills, Taylor S., Niño, Katia E., Davizon-Castillo, Pavel, Pietras, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870714/
https://www.ncbi.nlm.nih.gov/pubmed/35203330
http://dx.doi.org/10.3390/cells11040680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8870714/
https://www.ncbi.nlm.nih.gov/pubmed/35203330
http://dx.doi.org/10.3390/cells11040680

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