CRL4(Cdt2) Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA

The ubiquitin ligase CRL4(Cdt2) plays a vital role in preserving genomic integrity by regulating essential proteins during S phase and after DNA damage. Deregulation of CRL4(Cdt2) during the cell cycle can cause DNA re-replication, which correlates with malignant transformation and tumor growth. CRL...

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Detalles Bibliográficos
Autores principales: Mazian, Muadz Ahmad, Yamanishi, Kumpei, Rahman, Mohd Zulhilmi Abdul, Ganasen, Menega, Nishitani, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871960/
https://www.ncbi.nlm.nih.gov/pubmed/35205311
http://dx.doi.org/10.3390/genes13020266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871960/
https://www.ncbi.nlm.nih.gov/pubmed/35205311
http://dx.doi.org/10.3390/genes13020266

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