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CRL4(Cdt2) Ubiquitin Ligase, A Genome Caretaker Controlled by Cdt2 Binding to PCNA and DNA

The ubiquitin ligase CRL4(Cdt2) plays a vital role in preserving genomic integrity by regulating essential proteins during S phase and after DNA damage. Deregulation of CRL4(Cdt2) during the cell cycle can cause DNA re-replication, which correlates with malignant transformation and tumor growth. CRL...

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Detalles Bibliográficos
Autores principales:	Mazian, Muadz Ahmad, Yamanishi, Kumpei, Rahman, Mohd Zulhilmi Abdul, Ganasen, Menega, Nishitani, Hideo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8871960/ https://www.ncbi.nlm.nih.gov/pubmed/35205311 http://dx.doi.org/10.3390/genes13020266

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