Stalling of Eukaryotic Translesion DNA Polymerases at DNA-Protein Cross-Links

DNA-protein cross-links (DPCs) are extremely bulky adducts that interfere with replication. In human cells, they are processed by SPRTN, a protease activated by DNA polymerases stuck at DPCs. We have recently proposed the mechanism of the interaction of DNA polymerases with DPCs, involving a clash o...

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Detalles Bibliográficos
Autores principales: Yudkina, Anna V., Shilkin, Evgeniy S., Makarova, Alena V., Zharkov, Dmitry O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872012/
https://www.ncbi.nlm.nih.gov/pubmed/35205211
http://dx.doi.org/10.3390/genes13020166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872012/
https://www.ncbi.nlm.nih.gov/pubmed/35205211
http://dx.doi.org/10.3390/genes13020166

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