Leveraging Gene-Level Prediction as Informative Covariate in Hypothesis Weighting Improves Power for Rare Variant Association Studies

Gene-based rare variant association studies (RVASs) have low power due to the infrequency of rare variants and the large multiple testing burden. To correct for multiple testing, traditional false discovery rate (FDR) procedures which depend solely on P-values are often used. Recently, Independent H...

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Detalles Bibliográficos
Autores principales: Ji, Ying, Chen, Rui, Wang, Quan, Wei, Qiang, Tao, Ran, Li, Bingshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872452/
https://www.ncbi.nlm.nih.gov/pubmed/35205424
http://dx.doi.org/10.3390/genes13020381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872452/
https://www.ncbi.nlm.nih.gov/pubmed/35205424
http://dx.doi.org/10.3390/genes13020381

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