The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects

In RNA interference (RNAi), small interfering RNA (siRNA) suppresses the expression of its target mRNA with a perfect complementary sequence. In addition, siRNA also suppresses the expression of unintended mRNAs with partially complementary sequences mainly within the siRNA seed region (nucleotides...

Descripción completa

Detalles Bibliográficos
Autores principales: Kobayashi, Yoshiaki, Tian, Shen, Ui-Tei, Kumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872465/
https://www.ncbi.nlm.nih.gov/pubmed/35205363
http://dx.doi.org/10.3390/genes13020319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872465/
https://www.ncbi.nlm.nih.gov/pubmed/35205363
http://dx.doi.org/10.3390/genes13020319

Ejemplares similares