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The siRNA Off-Target Effect Is Determined by Base-Pairing Stabilities of Two Different Regions with Opposite Effects

In RNA interference (RNAi), small interfering RNA (siRNA) suppresses the expression of its target mRNA with a perfect complementary sequence. In addition, siRNA also suppresses the expression of unintended mRNAs with partially complementary sequences mainly within the siRNA seed region (nucleotides...

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Detalles Bibliográficos
Autores principales:	Kobayashi, Yoshiaki, Tian, Shen, Ui-Tei, Kumiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872465/ https://www.ncbi.nlm.nih.gov/pubmed/35205363 http://dx.doi.org/10.3390/genes13020319

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