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Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints
In order to target threatening pathogens, the adaptive immune system performs a continuous reorganization of its lymphocyte repertoire. Following an immune challenge, the B cell repertoire can evolve cells of increased specificity for the encountered strain. This process of affinity maturation gener...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872716/ https://www.ncbi.nlm.nih.gov/pubmed/35177475 http://dx.doi.org/10.1073/pnas.2113512119 |