Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome

FOXP1 syndrome caused by haploinsufficiency of the forkhead box protein P1 (FOXP1) gene is a neurodevelopmental disorder that manifests motor dysfunction, intellectual disability, autism, and language impairment. In this study, we used a Foxp1(+/−) mouse model to address whether cognitive and motor...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Fröhlich, Henning, Torres, Felipe Bodaleo, Silva, Rangel Leal, Poschet, Gernot, Agarwal, Amit, Rappold, Gudrun A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872729/
https://www.ncbi.nlm.nih.gov/pubmed/35165191
http://dx.doi.org/10.1073/pnas.2112852119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872729/
https://www.ncbi.nlm.nih.gov/pubmed/35165191
http://dx.doi.org/10.1073/pnas.2112852119

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