Multiple genetic paths including massive gene amplification allow Mycobacterium tuberculosis to overcome loss of ESX-3 secretion system substrates

Mycobacterium tuberculosis (Mtb) possesses five type VII secretion systems (T7SS), virulence determinants that include the secretion apparatus and associated secretion substrates. Mtb strains deleted for the genes encoding substrates of the ESX-3 T7SS, esxG or esxH, require iron supplementation for...

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Detalles Bibliográficos
Autores principales: Wang, Lin, Asare, Emmanuel, Shetty, Amol C., Sanchez-Tumbaco, Freddy, Edwards, Megan R., Saranathan, Rajagopalan, Weinrick, Brian, Xu, Jiayong, Chen, Bing, Bénard, Angèle, Dougan, Gordon, Leung, Daisy W., Amarasinghe, Gaya K., Chan, John, Basler, Christopher F., Jacobs, William R., Tufariello, JoAnn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872769/
https://www.ncbi.nlm.nih.gov/pubmed/35193958
http://dx.doi.org/10.1073/pnas.2112608119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872769/
https://www.ncbi.nlm.nih.gov/pubmed/35193958
http://dx.doi.org/10.1073/pnas.2112608119

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