Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

Safe and efficacious systemic delivery of messenger RNA (mRNA) to specific organs and cells in vivo remains the major challenge in the development of mRNA-based therapeutics. Targeting of systemically administered lipid nanoparticles (LNPs) coformulated with mRNA has largely been confined to the liv...

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Detalles Bibliográficos
Autores principales: Qiu, Min, Tang, Yan, Chen, Jinjin, Muriph, Rachel, Ye, Zhongfeng, Huang, Changfeng, Evans, Jason, Henske, Elizabeth P., Xu, Qiaobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872770/
https://www.ncbi.nlm.nih.gov/pubmed/35173043
http://dx.doi.org/10.1073/pnas.2116271119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872770/
https://www.ncbi.nlm.nih.gov/pubmed/35173043
http://dx.doi.org/10.1073/pnas.2116271119

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