Redox signaling by glutathione peroxidase 2 links vascular modulation to metabolic plasticity of breast cancer

In search of redox mechanisms in breast cancer, we uncovered a striking role for glutathione peroxidase 2 (GPx2) in oncogenic signaling and patient survival. GPx2 loss stimulates malignant progression due to reactive oxygen species/hypoxia inducible factor-α (HIF1α)/VEGFA (vascular endothelial growt...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Zuen, Liang, Huizhi, Galbo, Phillip M., Dharmaratne, Malindrie, Kulkarni, Ameya S., Fard, Atefeh Taherian, Aoun, Marie Louise, Martinez-Lopez, Nuria, Suyama, Kimita, Benard, Outhiriaradjou, Zheng, Wei, Liu, Yang, Albanese, Joseph, Zheng, Deyou, Mar, Jessica C., Singh, Rajat, Prystowsky, Michael B., Norton, Larry, Hazan, Rachel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872779/
https://www.ncbi.nlm.nih.gov/pubmed/35193955
http://dx.doi.org/10.1073/pnas.2107266119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872779/
https://www.ncbi.nlm.nih.gov/pubmed/35193955
http://dx.doi.org/10.1073/pnas.2107266119

Ejemplares similares