LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint

Retrotransposons are genomic DNA sequences that copy themselves to new genomic locations via RNA intermediates; LINE-1 is the only active and autonomous retrotransposon in the human genome. The mobility of LINE-1 is largely repressed in somatic tissues but is derepressed in many cancers, where LINE-...

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Detalles Bibliográficos
Autores principales: McKerrow, Wilson, Wang, Xuya, Mendez-Dorantes, Carlos, Mita, Paolo, Cao, Song, Grivainis, Mark, Ding, Li, LaCava, John, Burns, Kathleen H., Boeke, Jef D., Fenyö, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872788/
https://www.ncbi.nlm.nih.gov/pubmed/35169076
http://dx.doi.org/10.1073/pnas.2115999119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872788/
https://www.ncbi.nlm.nih.gov/pubmed/35169076
http://dx.doi.org/10.1073/pnas.2115999119

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