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Light-guided intrabodies for on-demand in situ target recognition in human cells

Due to their high stability and specificity in living cells, fluorescently labeled nanobodies are perfect probes for visualizing intracellular targets at an endogenous level. However, intrabodies bind unrestrainedly and hence may interfere with the target protein function. Here, we report a strategy...

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Detalles Bibliográficos
Autores principales: Joest, Eike F., Winter, Christian, Wesalo, Joshua S., Deiters, Alexander, Tampé, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872839/
https://www.ncbi.nlm.nih.gov/pubmed/35342543
http://dx.doi.org/10.1039/d1sc01331a