Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors

Ketamine produces a rapid antidepressant response in patients with major depressive disorder (MDD), but the underlying mechanisms appear multifaceted. One hypothesis, proposes that by antagonizing NMDA receptors on GABAergic interneurons, ketamine disinhibits afferens to glutamatergic principal neur...

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Detalles Bibliográficos
Autores principales: Lazarevic, Vesna, Yang, Yunting, Flais, Ivana, Svenningsson, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872981/
https://www.ncbi.nlm.nih.gov/pubmed/34376822
http://dx.doi.org/10.1038/s41380-021-01246-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872981/
https://www.ncbi.nlm.nih.gov/pubmed/34376822
http://dx.doi.org/10.1038/s41380-021-01246-3

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