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Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors
Ketamine produces a rapid antidepressant response in patients with major depressive disorder (MDD), but the underlying mechanisms appear multifaceted. One hypothesis, proposes that by antagonizing NMDA receptors on GABAergic interneurons, ketamine disinhibits afferens to glutamatergic principal neur...
Autores principales: | Lazarevic, Vesna, Yang, Yunting, Flais, Ivana, Svenningsson, Per |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8872981/ https://www.ncbi.nlm.nih.gov/pubmed/34376822 http://dx.doi.org/10.1038/s41380-021-01246-3 |
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