Defective IGF-1 prohormone N-glycosylation and reduced IGF-1 receptor signaling activation in congenital disorders of glycosylation

The insulin-like growth factor-1 (IGF-1) signaling pathway is crucial for the regulation of growth and development. The correct processing of the IGF-1Ea prohormone (proIGF-1Ea) and the IGF-1 receptor (IGF-1R) peptide precursor requires proper N-glycosylation. Deficiencies of N-linked glycosylation...

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Detalles Bibliográficos
Autores principales: Di Patria, Laura, Annibalini, Giosuè, Morrone, Amelia, Ferri, Lorenzo, Saltarelli, Roberta, Galluzzi, Luca, Diotallevi, Aurora, Bocconcelli, Matteo, Donati, Maria Alice, Barone, Rita, Guerrini, Renzo, Jaeken, Jaak, Stocchi, Vilberto, Barbieri, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873121/
https://www.ncbi.nlm.nih.gov/pubmed/35211808
http://dx.doi.org/10.1007/s00018-022-04180-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873121/
https://www.ncbi.nlm.nih.gov/pubmed/35211808
http://dx.doi.org/10.1007/s00018-022-04180-x

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