New transgenic mouse models enabling pan-hematopoietic or selective hematopoietic stem cell depletion in vivo

Hematopoietic stem cell (HSC) multipotency and self-renewal are typically defined through serial transplantation experiments. Host conditioning is necessary for robust HSC engraftment, likely by reducing immune-mediated rejection and by clearing limited HSC niche space. Because irradiation of the re...

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Detalles Bibliográficos
Autores principales: Rodriguez y Baena, Alessandra, Rajendiran, Smrithi, Manso, Bryce A., Krietsch, Jana, Boyer, Scott W., Kirschmann, Jessica, Forsberg, E. Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873235/
https://www.ncbi.nlm.nih.gov/pubmed/35210475
http://dx.doi.org/10.1038/s41598-022-07041-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873235/
https://www.ncbi.nlm.nih.gov/pubmed/35210475
http://dx.doi.org/10.1038/s41598-022-07041-6

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