A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping the fast Myosin genes. By 4C-seq we show that active fast Myosin promoters interact with this super-enhancer by DNA loo...

Descripción completa

Detalles Bibliográficos
Autores principales: Dos Santos, Matthieu, Backer, Stéphanie, Auradé, Frédéric, Wong, Matthew Man-Kin, Wurmser, Maud, Pierre, Rémi, Langa, Francina, Do Cruzeiro, Marcio, Schmitt, Alain, Concordet, Jean-Paul, Sotiropoulos, Athanassia, Jeffrey Dilworth, F., Noordermeer, Daan, Relaix, Frédéric, Sakakibara, Iori, Maire, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873246/
https://www.ncbi.nlm.nih.gov/pubmed/35210422
http://dx.doi.org/10.1038/s41467-022-28666-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873246/
https://www.ncbi.nlm.nih.gov/pubmed/35210422
http://dx.doi.org/10.1038/s41467-022-28666-1

Ejemplares similares