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Cellular fractionation reveals transcriptome responses of human fibroblasts to UV-C irradiation

While cells activate a multifaceted DNA damage response to remove transcription-blocking DNA lesions, mechanisms to regulate genome-wide reduction of RNA synthesis and the paradoxical continuous loading of RNAP II at initiation sites are still poorly understood. Uncovering how dramatic changes to th...

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Detalles Bibliográficos
Autores principales: Liu, Jiena, Wu, Zhenzhen, He, Jin, Wang, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873393/
https://www.ncbi.nlm.nih.gov/pubmed/35210409
http://dx.doi.org/10.1038/s41419-022-04634-x