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Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay
Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple receptors. Here, we describe a multiplex reporter assay (t...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873415/ https://www.ncbi.nlm.nih.gov/pubmed/35210493 http://dx.doi.org/10.1038/s41598-022-07031-8 |