Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay

Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple receptors. Here, we describe a multiplex reporter assay (t...

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Detalles Bibliográficos
Autores principales: Medvedev, Alexander, Moeser, Matt, Medvedeva, Liubov, Martsen, Elena, Granick, Alexander, Raines, Lydia, Gorman, Kristen, Lin, Benjamin, Zeng, Ming, Houck, Keith A., Makarov, Sergei S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873415/
https://www.ncbi.nlm.nih.gov/pubmed/35210493
http://dx.doi.org/10.1038/s41598-022-07031-8

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