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Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel
The elusive activation/deactivation mechanism of hERG is investigated, a voltage-gated potassium channel involved in severe inherited and drug-induced cardiac channelopathies, including the Long QT Syndrome. Firstly, the available structural data are integrated by providing a homology model for the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873449/ https://www.ncbi.nlm.nih.gov/pubmed/35210539 http://dx.doi.org/10.1038/s42003-022-03074-9 |