Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly

Human islet amyloid polypeptide (hIAPP) self-assembles into amyloid fibrils which deposit in pancreatic islets of type 2 diabetes (T2D) patients. Here, we applied chemical kinetics to study the mechanism of amyloid assembly of wild-type hIAPP and its more amyloidogenic natural variant S20G. We show...

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Detalles Bibliográficos
Autores principales: Xu, Yong, Maya-Martinez, Roberto, Guthertz, Nicolas, Heath, George R., Manfield, Iain W., Breeze, Alexander L., Sobott, Frank, Foster, Richard, Radford, Sheena E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873464/
https://www.ncbi.nlm.nih.gov/pubmed/35210421
http://dx.doi.org/10.1038/s41467-022-28660-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873464/
https://www.ncbi.nlm.nih.gov/pubmed/35210421
http://dx.doi.org/10.1038/s41467-022-28660-7

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