Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy

Anxiety and depression affect 35–50% of patients with Parkinson’s disease (PD), often precede the onset of motor symptoms, and have a negative impact on their quality of life. Dysfunction of the serotonergic (5-HT) system, which regulates mood and emotional pathways, occurs during the premotor phase...

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Detalles Bibliográficos
Autores principales: Miquel-Rio, Lluis, Alarcón-Arís, Diana, Torres-López, María, Cóppola-Segovia, Valentín, Pavia-Collado, Rubén, Paz, Verónica, Ruiz-Bronchal, Esther, Campa, Leticia, Casal, Carme, Montefeltro, Andrés, Vila, Miquel, Artigas, Francesc, Revilla, Raquel, Bortolozzi, Analia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873470/
https://www.ncbi.nlm.nih.gov/pubmed/35210396
http://dx.doi.org/10.1038/s41398-022-01842-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873470/
https://www.ncbi.nlm.nih.gov/pubmed/35210396
http://dx.doi.org/10.1038/s41398-022-01842-z

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