Structural basis of adenylyl cyclase 9 activation

Adenylyl cyclase 9 (AC9) is a membrane-bound enzyme that converts ATP into cAMP. The enzyme is weakly activated by forskolin, fully activated by the G protein Gαs subunit and is autoinhibited by the AC9 C-terminus. Although our recent structural studies of the AC9-Gαs complex provided the framework...

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Detalles Bibliográficos
Autores principales: Qi, Chao, Lavriha, Pia, Mehta, Ved, Khanppnavar, Basavraj, Mohammed, Inayathulla, Li, Yong, Lazaratos, Michalis, Schaefer, Jonas V., Dreier, Birgit, Plückthun, Andreas, Bondar, Ana-Nicoleta, Dessauer, Carmen W., Korkhov, Volodymyr M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873477/
https://www.ncbi.nlm.nih.gov/pubmed/35210418
http://dx.doi.org/10.1038/s41467-022-28685-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873477/
https://www.ncbi.nlm.nih.gov/pubmed/35210418
http://dx.doi.org/10.1038/s41467-022-28685-y

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