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SUMOylation of PDPK1 Is required to maintain glycolysis-dependent CD4 T-cell homeostasis

The immune system is finely tuned to fight against infections, eradicate neoplasms, and prevent autoimmunity. Protein posttranslational modification (PTM) constitutes a molecular layer of regulation to guarantee the proper intensity of immune response. Herein, we report that UBC9-mediated protein SU...

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Detalles Bibliográficos
Autores principales: Sun, Fei, Wang, Fa-Xi, Zhu, He, Yue, Tian-Tian, Yang, Chun-Liang, Luo, Jia-Hui, Luo, Xi, Zhou, Hai-Feng, Rong, Shan-Jie, Lu, Wan-Ying, Zhou, Qing, Yang, Ping, Xiong, Fei, Liu, Yan-Jun, Yan, Tong, Liao, Yun-Fei, Zhang, Shu, Wang, Cong-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873481/
https://www.ncbi.nlm.nih.gov/pubmed/35210408
http://dx.doi.org/10.1038/s41419-022-04622-1