Cargando…

SUMOylation of PDPK1 Is required to maintain glycolysis-dependent CD4 T-cell homeostasis

The immune system is finely tuned to fight against infections, eradicate neoplasms, and prevent autoimmunity. Protein posttranslational modification (PTM) constitutes a molecular layer of regulation to guarantee the proper intensity of immune response. Herein, we report that UBC9-mediated protein SU...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Fei, Wang, Fa-Xi, Zhu, He, Yue, Tian-Tian, Yang, Chun-Liang, Luo, Jia-Hui, Luo, Xi, Zhou, Hai-Feng, Rong, Shan-Jie, Lu, Wan-Ying, Zhou, Qing, Yang, Ping, Xiong, Fei, Liu, Yan-Jun, Yan, Tong, Liao, Yun-Fei, Zhang, Shu, Wang, Cong-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8873481/ https://www.ncbi.nlm.nih.gov/pubmed/35210408 http://dx.doi.org/10.1038/s41419-022-04622-1

Ejemplares similares

Ubc9 regulates the expression of MHC II in dendritic cells to enhance DSS-induced colitis by mediating RBPJ SUMOylation
por: Zhang, Jing, et al.
Publicado: (2023)

Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin
por: Zhang, Tao, et al.
Publicado: (2022)

Downregulating PDPK1 and taking phillyrin as PDPK1-targeting drug protect hepatocytes from alcoholic steatohepatitis by promoting autophagy
por: Zhang, Yuan, et al.
Publicado: (2022)

MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis
por: Yue, Tiantian, et al.
Publicado: (2021)

Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis
por: Zhou, Wen, et al.
Publicado: (2023)

Revisiting the Antigen-Presenting Function of β Cells in T1D Pathogenesis
por: Li, Yang, et al.
Publicado: (2021)

Aloperine Ameliorates IMQ-Induced Psoriasis by Attenuating Th17 Differentiation and Facilitating Their Conversion to Treg
por: Zhou, Hai-Feng, et al.
Publicado: (2022)

Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection
por: Hu, Yong-jian, et al.
Publicado: (2023)

SUMOylation in Skeletal Development, Homeostasis, and Disease
por: Liu, Huadie, et al.
Publicado: (2022)

SUMOylation in the control of cholesterol homeostasis
por: Talamillo, Ana, et al.
Publicado: (2020)

Cigarette smoke extract stimulates bronchial epithelial cells to undergo a SUMOylation turnover
por: Zhou, Haifeng, et al.
Publicado: (2020)

SUMOylation in α-Synuclein Homeostasis and Pathology
por: Savyon, Mor, et al.
Publicado: (2020)

CircRNA ANXA2 Promotes Lung Cancer Proliferation and Metastasis by Upregulating PDPK1 Expression
por: Ju, Yan, et al.
Publicado: (2021)

Arginine metabolism regulates the pathogenesis of inflammatory bowel disease
por: Li, Jun-Yi, et al.
Publicado: (2022)

The role of hydrogen sulphide signalling in macrophage activation
por: Sun, Fei, et al.
Publicado: (2020)

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis
por: Kim, Dong-Hyun, et al.
Publicado: (2016)

Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm
por: Liu, Lijie, et al.
Publicado: (2022)

Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939
por: Yang, Jun, et al.
Publicado: (2017)

RSK1 SUMOylation is required for KSHV lytic replication
por: Liu, Zhenshan, et al.
Publicado: (2021)

Loss of PDPK1 abrogates resistance to gemcitabine in label-retaining pancreatic cancer cells
por: Li, Dandan, et al.
Publicado: (2018)

Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis
por: Yu, Yu, et al.
Publicado: (2022)

Phosphoinositide‐dependent Kinase‐1 (PDPK1) regulates serum/glucocorticoid‐regulated Kinase 3 (SGK3) for prostate cancer cell survival
por: Nalairndran, Geetha, et al.
Publicado: (2020)

Lycopene Maintains Mitochondrial Homeostasis to Counteract the Enterotoxicity of Deoxynivalenol
por: Cai, Zihui, et al.
Publicado: (2023)

The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway
por: Sun, Zihao, et al.
Publicado: (2018)

The Essential Role of FoxO1 in the Regulation of Macrophage Function
por: Rong, Shan Jie, et al.
Publicado: (2022)

NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota
por: Huang, Pan, et al.
Publicado: (2021)

gga-miR-148a-5p-Targeting PDPK1 Inhibits Proliferation and Cell Cycle Progression of Avain Leukosis Virus Subgroup J (ALV-J)-Infected Cells
por: Yu, Heling, et al.
Publicado: (2020)

PAX6, modified by SUMOylation, plays a protective role in corneal endothelial injury
por: Yu, Fei, et al.
Publicado: (2020)

Interaction between glycolysis‒cholesterol synthesis axis and tumor microenvironment reveal that gamma-glutamyl hydrolase suppresses glycolysis in colon cancer
por: Chen, Yan-Jie, et al.
Publicado: (2022)

Pancreatic draining lymph nodes (PLNs) serve as a pathogenic hub contributing to the development of type 1 diabetes
por: Sun, Fei, et al.
Publicado: (2023)

SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
por: Yu, Xiaoyan, et al.
Publicado: (2018)

Increased glycolysis in skeletal muscle coordinates with adipose tissue in systemic metabolic homeostasis
por: Xiang, Cong, et al.
Publicado: (2021)

Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk
por: Luo, Hui-Huan, et al.
Publicado: (2020)

Intact endothelial autophagy is required to maintain vascular lipid homeostasis
por: Torisu, Kumiko, et al.
Publicado: (2015)

Possible involvement of the Hedgehog and PDPK1–Akt pathways in the growth and migration of small-cell lung cancer
por: Tang, Naiwang, et al.
Publicado: (2021)

TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain
por: Wang, Yan, et al.
Publicado: (2018)

Role for Sumoylation in Systemic Inflammation and Immune Homeostasis in Drosophila Larvae
por: Paddibhatla, Indira, et al.
Publicado: (2010)

α-Mangostin Alleviated HIF-1α-Mediated Angiogenesis in Rats With Adjuvant-Induced Arthritis by Suppressing Aerobic Glycolysis
por: Jiang, Tian-Tian, et al.
Publicado: (2021)

TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury
por: Zhong, Wen-Jing, et al.
Publicado: (2023)

Requirement for PINCH in skeletal myoblast differentiation
por: Liao, Huimin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gqc8ol6v0ea4nkaol8806js4ff