Cargando…

Avasimibe Alleviates Disruption of the Airway Epithelial Barrier by Suppressing the Wnt/β-Catenin Signaling Pathway

Avasimibe (Ava) is an acetyl-CoA acetyltransferase 1 (ACAT1) specific inhibitor and an established medicine for atherosclerosis, owing to its excellent and safe anti-inflammation effects in humans. However, its efficacy in asthma has not yet been reported. We first administered varying concentration...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Zicong, Liang, Shixiu, Zhou, Zili, Liu, Jieyi, Meng, Xiaojing, Zou, Fei, Yu, Changhui, Cai, Shaoxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874122/ https://www.ncbi.nlm.nih.gov/pubmed/35222024 http://dx.doi.org/10.3389/fphar.2022.795934

Ejemplares similares

House dust mite disrupts the airway epithelial barrier by affecting the expression of thymic stromal lymphopoietin through inducing Atg5
por: Zhou, Zicong, et al.
Publicado: (2023)

TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts
por: Zhou, Zili, et al.
Publicado: (2023)

Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin
por: Yu, Changhui, et al.
Publicado: (2022)

Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases
por: Hasan, Md Kamrul, et al.
Publicado: (2022)

Distinct roles of short and long thymic stromal lymphopoietin isoforms in house dust mite-induced asthmatic airway epithelial barrier disruption
por: Dong, Hangming, et al.
Publicado: (2016)

Potentiation of Kras peptide cancer vaccine by avasimibe, a cholesterol modulator
por: Pan, Jing, et al.
Publicado: (2019)

Orai3 mediates Orai channel remodelling to activate fibroblast in pulmonary fibrosis
por: Yu, Changhui, et al.
Publicado: (2022)

Lcz696 Alleviates Myocardial Fibrosis After Myocardial Infarction Through the sFRP-1/Wnt/β-Catenin Signaling Pathway
por: Liu, Jing, et al.
Publicado: (2021)

Synergy of Dendritic Cell Vaccines and Avasimibe in Treatment of Head and Neck Cancer in Mice
por: Chen, Xin, et al.
Publicado: (2017)

Astragaloside IV Alleviates Intestinal Barrier Dysfunction via the AKT-GSK3β-β-Catenin Pathway in Peritoneal Dialysis
por: He, Jiaqi, et al.
Publicado: (2022)

Breaching the Delivery Barrier: Chemical and Physical Airway Epithelium Disruption Strategies for Enhancing Lentiviral-Mediated Gene Therapy
por: McCarron, Alexandra, et al.
Publicado: (2021)

Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signaling
por: Bernaudo, S, et al.
Publicado: (2016)

Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury
por: Wang, Chunhong, et al.
Publicado: (2022)

Regulatory Mechanisms of the Wnt/β-Catenin Pathway in Diabetic Cutaneous Ulcers
por: Zhang, Han, et al.
Publicado: (2018)

AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer
por: Zhang, Kaiming, et al.
Publicado: (2018)

USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/β-Catenin Pathway
por: Xue, Sudong, et al.
Publicado: (2020)

Arctigenin Attenuates Tumor Metastasis Through Inhibiting Epithelial–Mesenchymal Transition in Hepatocellular Carcinoma via Suppressing GSK3β-Dependent Wnt/β-Catenin Signaling Pathway In Vivo and In Vitro
por: Lu, Zheng, et al.
Publicado: (2019)

Artemisinin analog SM934 alleviates epithelial barrier dysfunction via inhibiting apoptosis and caspase-1-mediated pyroptosis in experimental colitis
por: Shao, Meijuan, et al.
Publicado: (2022)

Nintedanib Inhibits Wnt3a-Induced Myofibroblast Activation by Suppressing the Src/β-Catenin Pathway
por: Li, Xiaohe, et al.
Publicado: (2020)

Erratum: Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signalling
por: Bernaudo, S, et al.
Publicado: (2016)

Aberrant Wnt/Beta-Catenin Pathway Activation in Dialysate-Induced Peritoneal Fibrosis
por: Guo, Yuanyuan, et al.
Publicado: (2017)

Interplay Between Ion Channels and the Wnt/β-Catenin Signaling Pathway in Cancers
por: Rapetti-Mauss, Raphael, et al.
Publicado: (2020)

Corrigendum: AFAP1-AS1 Promotes Epithelial-Mesenchymal Transition and Tumorigenesis Through Wnt/β-Catenin Signaling Pathway in Triple-Negative Breast Cancer
por: Zhang, Kaiming, et al.
Publicado: (2020)

Corrigendum: USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/β-Catenin Pathway
por: Xue, Sudong, et al.
Publicado: (2020)

Sivelestat Alleviates Atherosclerosis by Improving Intestinal Barrier Function and Reducing Endotoxemia
por: Nie, Hezhongrong, et al.
Publicado: (2022)

PKC-ζ Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/β-Catenin Signaling
por: Cao, Yan-Jun, et al.
Publicado: (2022)

Editorial: Non-coding RNA and Wnt/β-Catenin Signaling Pathway in Human Cancer
por: Waye, Mary Miu Yee, et al.
Publicado: (2022)

Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway
por: Zhao, Jing, et al.
Publicado: (2023)

Total Flavonoids of Rhizoma Drynariae Promotes Differentiation of Osteoblasts and Growth of Bone Graft in Induced Membrane Partly by Activating Wnt/β-Catenin Signaling Pathway
por: Li, Shuyuan, et al.
Publicado: (2021)

Glycyrrhizic Acid Promotes Osteogenic Differentiation of Human Bone Marrow Stromal Cells by Activating the Wnt/β-Catenin Signaling Pathway
por: Bai, Jinwu, et al.
Publicado: (2021)

Avasimibe inhibits tumor growth by targeting FoxM1-AKR1C1 in osteosarcoma
por: Wang, Liang, et al.
Publicado: (2019)

Avasimibe Dampens Cholangiocarcinoma Progression by Inhibiting FoxM1-AKR1C1 Signaling
por: Gao, Yunshu, et al.
Publicado: (2021)

Corrigendum: Total Flavonoids of Rhizoma Drynariae Promotes Differentiation of Osteoblasts and Growth of Bone Graft in Induced Membrane Partly by Activating Wnt/β-Catenin Signaling Pathway
por: Li, Shuyuan, et al.
Publicado: (2021)

ACE2 Expression in Organotypic Human Airway Epithelial Cultures and Airway Biopsies
por: Chen, Qianyu, et al.
Publicado: (2022)

Astragalus polysaccharides and astragaloside IV alleviate inflammation in bovine mammary epithelial cells by regulating Wnt/β-catenin signaling pathway
por: Fan, Jiaqi, et al.
Publicado: (2022)

The Ameliorative Effect of Mahuang Fuzi and Shenzhuo Decoction on Membranous Nephropathy of Rodent Model is Associated With Autophagy and Wnt/β-Catenin Pathway
por: Gao, Yu, et al.
Publicado: (2022)

Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD
por: Xu, Yifan, et al.
Publicado: (2022)

A Cell Model Suitable for a High-Throughput Screening of Inhibitors of the Wnt/β-Catenin Pathway
por: Grimaldi, Marina, et al.
Publicado: (2018)

Wnt/β-Catenin Pathway-Regulated Fibromodulin Expression Is Crucial for Breast Cancer Metastasis and Inhibited by Aspirin
por: Khan, Fahim Ullah, et al.
Publicado: (2019)

Targeting the Wnt/β-Catenin Signaling Pathway as a Potential Therapeutic Strategy in Renal Tubulointerstitial Fibrosis
por: Li, Shan-Shan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_arsf3894t8eo2mgniurscue32b