Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression

Human brain organoid models that recapitulate the physiology and complexity of the human brain have a great potential for in vitro disease modeling, in particular for neurodegenerative diseases, such as Parkinson disease. In the present study, we compare single-cell RNA-sequencing data of human midb...

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Detalles Bibliográficos
Autores principales: Zagare, Alise, Barmpa, Kyriaki, Smajic, Semra, Smits, Lisa M., Grzyb, Kamil, Grünewald, Anne, Skupin, Alexander, Nickels, Sarah L., Schwamborn, Jens C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874228/
https://www.ncbi.nlm.nih.gov/pubmed/35077669
http://dx.doi.org/10.1016/j.ajhg.2021.12.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874228/
https://www.ncbi.nlm.nih.gov/pubmed/35077669
http://dx.doi.org/10.1016/j.ajhg.2021.12.009

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