Derivation of a Human In Vivo Benchmark Dose for Bisphenol A from ToxCast In Vitro Concentration Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation

A computational workflow which integrates physiologically based kinetic (PBK) modelling; global sensitivity analysis (GSA), Approximate Bayesian Computation (ABC), Markov Chain Monte Carlo (MCMC) simulation and the Virtual Cell Based Assay (VCBA) for the estimation of the active, free in vitro conce...

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Detalles Bibliográficos
Autores principales: Loizou, George, McNally, Kevin, Paini, Alicia, Hogg, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874249/
https://www.ncbi.nlm.nih.gov/pubmed/35222005
http://dx.doi.org/10.3389/fphar.2021.754408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874249/
https://www.ncbi.nlm.nih.gov/pubmed/35222005
http://dx.doi.org/10.3389/fphar.2021.754408

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