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The WNT/β-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes

INTRODUCTION: Aging is associated with cardiac myocyte loss, sarcopenia, and cardiac dysfunction. Adult cardiac myocytes are postmitotic cells with an insufficient proliferative capacity to compensate for myocyte loss. The canonical WNT (cWNT) pathway is involved in the regulation of cell cycle reen...

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Detalles Bibliográficos
Autores principales: Olcum, Melis, Cheedipudi, Sirisha M., Rouhi, Leila, Fan, Siyang, Jeong, Hyun-Hwan, Zhao, Zhongming, Gurha, Priyatansh, Marian, Ali J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874274/
https://www.ncbi.nlm.nih.gov/pubmed/35224561
http://dx.doi.org/10.20517/jca.2021.35