Cargando…

Pyrazole and Triazole Derivatives as Mycobacterium tuberculosis UDP-Galactopyranose Inhibitors

UDP-galactopyranose mutase (UGM) is an essential enzyme involved in the bacterial cell wall synthesis, and is not present in mammalian cells. Thus, UGM from Mycobacterium tuberculosis (Mtb) represents a novel and attractive drug target for developing antituberculosis agents. A pyrazole-based compoun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmed, Dalia M., Chen, Jeffrey M., Sanders, David A. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874540/ https://www.ncbi.nlm.nih.gov/pubmed/35215309 http://dx.doi.org/10.3390/ph15020197

Ejemplares similares

Identification of Aspergillus fumigatus UDP-Galactopyranose Mutase Inhibitors
por: Martin del Campo, Julia S., et al.
Publicado: (2017)

Author Correction: Identification of Aspergillus fumigatus UDP-Galactopyranose Mutase Inhibitors
por: Martin del Campo, Julia S., et al.
Publicado: (2018)

QM/MM Molecular Dynamics Study of the Galactopyranose → Galactofuranose Reaction Catalysed by Trypanosoma cruzi UDP-Galactopyranose Mutase
por: Pierdominici-Sottile, Gustavo, et al.
Publicado: (2014)

Targeting UDP-Galactopyranose Mutases from Eukaryotic Human Pathogens
por: Kizjakina, Karina, et al.
Publicado: (2013)

In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction
por: Mehra-Chaudhary, Ritcha, et al.
Publicado: (2016)

Structural Insight into the Unique Substrate Binding Mechanism and Flavin Redox State of UDP-galactopyranose Mutase from Aspergillus fumigatus
por: van Straaten, Karin E., et al.
Publicado: (2012)

Fluorescence Polarization Binding Assay for Aspergillus fumigatus Virulence Factor UDP-Galactopyranose Mutase
por: Qi, Jun, et al.
Publicado: (2011)

Purification, crystallization and preliminary X-ray diffraction data of UDP-galactopyranose mutase from Aspergillus fumigatus
por: Penman, George A., et al.
Publicado: (2012)

Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors
por: Kishk, Safaa M., et al.
Publicado: (2019)

Aspergillus nidulans Cell Wall Composition and Function Change in Response to Hosting Several Aspergillus fumigatus UDP-Galactopyranose Mutase Activity Mutants
por: Alam, Md Kausar, et al.
Publicado: (2014)

UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase
por: Ma, Liang, et al.
Publicado: (2017)

Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics
por: Da Fonseca, Isabel, et al.
Publicado: (2014)

Cynaroside inhibits Leishmania donovani UDP-galactopyranose mutase and induces reactive oxygen species to exert antileishmanial response
por: Tabrez, Shams, et al.
Publicado: (2021)

Chemical Mechanism of UDP-Galactopyranose Mutase from Trypanosoma cruzi: A Potential Drug Target against Chagas' Disease
por: Oppenheimer, Michelle, et al.
Publicado: (2012)

RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae
por: Misra, Sweta, et al.
Publicado: (2017)

Synthesis, biological evaluation and computational studies of pyrazole derivatives as Mycobacterium tuberculosis CYP121A1 inhibitors
por: Alshabani, Lama A., et al.
Publicado: (2022)

Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents
por: Chu, Ming-Jie, et al.
Publicado: (2019)

NSC 18725, a Pyrazole Derivative Inhibits Growth of Intracellular Mycobacterium tuberculosis by Induction of Autophagy
por: Arora, Garima, et al.
Publicado: (2020)

Rv3634c from Mycobacterium tuberculosis H37Rv encodes an enzyme with UDP-Gal/Glc and UDP-GalNAc 4-epimerase activities
por: Pardeshi, Peehu, et al.
Publicado: (2017)

Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome
por: Rožman, Kaja, et al.
Publicado: (2020)

UDP-Galactose 4′-Epimerase Activities toward UDP-Gal and UDP-GalNAc Play Different Roles in the Development of Drosophila melanogaster
por: Daenzer, Jennifer M. I., et al.
Publicado: (2012)

Aligned TiO(2) Scaffolds in the Presence of a Galactopyranose Matrix by Sol-Gel Process
por: Romero, Humberto Alejandro Monreal, et al.
Publicado: (2023)

Selective, Tunable O(2) Binding in Cobalt(II)–Triazolate/Pyrazolate Metal–Organic Frameworks
por: Xiao, Dianne J., et al.
Publicado: (2016)

The structure-activity relationship of the salicylimide derived inhibitors of UDP-sugar producing pyrophosphorylases
por: Decker, Daniel, et al.
Publicado: (2018)

Synthesis, antimicrobial and antioxidant activity of triazole, pyrazole containing thiazole derivatives and molecular docking studies on COVID-19
por: Matta, Raghavender, et al.
Publicado: (2023)

Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties
por: Elhady, Heba A., et al.
Publicado: (2018)

New 1,2,3-Triazole-Appended Bis-pyrazoles: Synthesis, Bioevaluation, and Molecular Docking
por: Danne, Ashruba B., et al.
Publicado: (2021)

Synthesis and Analgesic Activity of Some New Pyrazoles and Triazoles Bearing a 6,8-Dibromo-2-methylquinazoline Moiety
por: Saad, Hosam A., et al.
Publicado: (2011)

UDP-xylose and UDP-galactose synthesis in Trichomonas vaginalis
por: Rosenberger, Andrea F.N., et al.
Publicado: (2012)

Crystal structure of 1,2,3,4-di-O-methylene-α-d-galactopyranose
por: Tiritiris, Ioannis, et al.
Publicado: (2015)

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor
por: Raimi, Olawale G., et al.
Publicado: (2020)

Biosynthesis of UDP-xylose and UDP-arabinose in Sinorhizobium meliloti 1021: first characterization of a bacterial UDP-xylose synthase, and UDP-xylose 4-epimerase
por: Gu, Xiaogang, et al.
Publicado: (2011)

Pyrazole, imidazole and triazole: In silico, docking and ADMET studies against SARS-CoV-2
por: Mohamed, Mounir, et al.
Publicado: (2023)

Coordination Complexes Built from a Ditopic Triazole-Pyrazole Ligand with Antibacterial and Antifungal Performances
por: Draoui, Youssef, et al.
Publicado: (2023)

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors
por: Borodkin, Vladimir S., et al.
Publicado: (2014)

Elucidation of Substrate Specificity in Aspergillus nidulans UDP-Galactose-4-Epimerase
por: Dalrymple, Sean A., et al.
Publicado: (2013)

Novel Anticancer Fused Pyrazole Derivatives as EGFR and VEGFR-2 Dual TK Inhibitors
por: Saleh, Nashwa M., et al.
Publicado: (2020)

Identification of UDP-rhamnosyltransferases and UDP-galactosyltransferase involved in flavonol glycosylation in Morella rubra
por: Ren, Chuanhong, et al.
Publicado: (2022)

Design, Synthesis, and In Vitro and In Vivo Antifungal Activity of Novel Triazoles Containing Phenylethynyl Pyrazole Side Chains
por: Ni, Tingjunhong, et al.
Publicado: (2022)

6-[Bis(ethoxycarbonyl)methyl]-6-deoxy-1,2;3,4-di-O-isopropylidene-d-galactopyranose
por: Doboszewski, Bogdan, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_eumplagrgb9kqpd377gcqgcdf1